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TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Airoldi, Chiara A 
Hearn, Timothy J 
Brockington, Samuel F  ORCID logo  https://orcid.org/0000-0003-1216-219X

Abstract

The Arabidopsis genome contains three genes encoding proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD-repeat (WDR) subfamily. TTG1 is a known regulator of epidermal cell differentiation and pigment production, while LIGHT-REGULATED WD1 and LIGHT-REGULATED WD2 are known regulators of the circadian clock. Here, we discovered a new central role for TTG1 WDR proteins as regulators of the circadian system, as evidenced by the lack of detectable circadian rhythms in a triple lwd1 lwd2 ttg1 mutant. This shows that there has been subfunctionalization via protein changes within the angiosperms, with some TTG1 WDR proteins developing a stronger role in circadian clock regulation while losing the protein characteristics essential for pigment production and epidermal cell specification, and others weakening their ability to drive circadian clock regulation. Our work shows that even where proteins are very conserved, small changes can drive big functional differences.

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Keywords

Arabidopsis, Arabidopsis Proteins, Cell Differentiation, Pigmentation, Plant Cells, Plant Epidermis

Journal Title

Nat Plants

Conference Name

Journal ISSN

2055-026X
2055-0278

Volume Title

5

Publisher

Springer Science and Business Media LLC

Rights

All rights reserved
Sponsorship
Leverhulme Trust (RPG-2018-318)
Biotechnology and Biological Sciences Research Council (BB/M006212/1)
CAA acknowledges support from the Cambridge University Botanic Garden Research Fund. TJH was supported by BBSRC UK grant BB/M006212/1 awarded to AARW.