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An amphiphilic-DNA platform for the design of crystalline frameworks with programmable structure and functionality

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cam.issuedOnline2018-10-23
datacite.isderivedfrom.doi10.26434/chemrxiv.7203296.v1
dc.contributor.authorBrady, Ryan
dc.contributor.authorBrooks, Nicholas
dc.contributor.authorFodara, Vito
dc.contributor.authorCicuta, Pietro
dc.contributor.authorDi Michele, L
dc.contributor.orcidCicuta, Pietro [0000-0002-9193-8496]
dc.contributor.orcidDi Michele, Lorenzo [0000-0002-1458-9747]
dc.date.accessioned2018-11-24T00:31:34Z
dc.date.available2018-11-24T00:31:34Z
dc.date.issued2018-11-14
dc.description.abstractThe reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, along with their facile synthesis and breadth of available functionalizations, DNA Nanotechnology is widely acknowledged as a prime route for the rational design of nanostructured materials. Yet, the preparation of crystalline DNA frameworks with programmable structure and functionality remains a challenge. Here we demonstrate the potential of simple amphiphilic DNA motifs, dubbed C-stars, as a versatile platform for the design of programmable DNA crystals. In contrast to all-DNA materials, in which structure depends on the precise molecular details of individual build-ing blocks, the self-assembly of C-stars is controlled uniquely by their topology and symmetry. Exploiting this robust self-assembly principle we design a range of topologically identical, but structurally and chemically distinct C-stars that following a one-pot reaction self- assemble into highly porous, functional, crystalline frameworks. Simple design variations allow us to fine-tune the lattice parameter and thus control the partitioning of macromolecules within the frameworks, embed responsive motifs that can induce isothermal disassembly, and include chemical moieties to capture target proteins specifically and reversibly.
dc.description.sponsorshipLDM, PC and NJB acknowledge support from the EPSRC Programme Grant CAPITALS number EP/J017566/1. LDM acknowledges support from the Leverhulme Trust and the Isaac Newton Trust through an Early Career Fellow- 9 ship (ECF-2015-494) and from the Royal Society through a University Research Fellowship (UF160152). RAB acknowledges support from the EPSRC CDT in Nanoscience and Nanotechnology (NanoDTC), grant number EP/L015978/1.
dc.identifier.doi10.17863/CAM.33280
dc.identifier.eissn1520-5126
dc.identifier.issn1520-5126
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285953
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.publisher.urlhttp://dx.doi.org/10.1021/jacs.8b09143
dc.subjectDNA
dc.subjectGreen Fluorescent Proteins
dc.subjectNanostructures
dc.subjectNanotechnology
dc.subjectNucleic Acid Conformation
dc.subjectOsmolar Concentration
dc.subjectParticle Size
dc.subjectSurface-Active Agents
dc.titleAn amphiphilic-DNA platform for the design of crystalline frameworks with programmable structure and functionality
dc.typeArticle
dcterms.dateAccepted2018-10-23
prism.publicationNameJournal of the American Chemical Society
pubs.funder-project-idLeverhulme Trust (ECF-2015-494)
pubs.funder-project-idIsaac Newton Trust (MIN 1508(S))
pubs.funder-project-idRoyal Society (UF160152)
pubs.funder-project-idRoyal Society (RGF/R1/180043)
pubs.funder-project-idEPSRC (via Imperial College London) (CHIS_P39012)
pubs.funder-project-idEPSRC (1494571)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/L015978/1)
rioxxterms.licenseref.startdate2018-10-23
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1021/jacs.8b09143

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