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Cell-Free Mitochondrial DNA in Acute Brain Injury.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Kayhanian, Saeed 
Glynos, Angelos 
Mair, Richard 
Lakatos, Andras 
Hutchinson, Peter JA 

Abstract

Traumatic brain injury and aneurysmal subarachnoid haemorrhage are a major cause of morbidity and mortality worldwide. Treatment options remain limited and are hampered by our understanding of the cellular and molecular mechanisms, including the inflammatory response observed in the brain. Mitochondrial DNA (mtDNA) has been shown to activate an innate inflammatory response by acting as a damage-associated molecular pattern (DAMP). Here, we show raised circulating cell-free (ccf) mtDNA levels in both cerebrospinal fluid (CSF) and serum within 48 h of brain injury. CSF ccf-mtDNA levels correlated with clinical severity and the interleukin-6 cytokine response. These findings support the use of ccf-mtDNA as a biomarker after acute brain injury linked to the inflammatory disease mechanism.

Description

Keywords

DAMP, acute brain injury, brain inflammation, mitochondrial DNA, subarachnoid hemorrhage, traumatic brain injury

Journal Title

Neurotrauma Rep

Conference Name

Journal ISSN

2689-288X
2689-288X

Volume Title

Publisher

Mary Ann Liebert Inc
Sponsorship
Wellcome Trust (212219/Z/18/Z)
MRC (MR/S035699/1)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Wellcome Trust (101876/Z/13/Z)
Engineering and Physical Sciences Research Council (EP/N01426X/1)
Medical Research Council (MC_UU_00015/7)