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Biomarkers predictive of treatment response in psoriasis and psoriatic arthritis: a systematic review.

Published version
Peer-reviewed

Type

Article

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Authors

Magee, Conor 
FitzGerald, Oliver M  ORCID logo  https://orcid.org/0000-0002-6607-6070
Jadon, Deepak R 

Abstract

AIMS: The ability to predict response to treatment remains a key unmet need in psoriatic disease. We conducted a systematic review of studies relating to biomarkers associated with response to treatment in either psoriasis vulgaris (PsV) or psoriatic arthritis (PsA). METHODS: A search was conducted in PubMed, Embase and the Cochrane library from their inception to 2 September 2020, and conference proceedings from four major rheumatology conferences. Original research articles studying pre-treatment biomarker levels associated with subsequent response to pharmacologic treatment in either PsV or PsA were included. RESULTS: A total of 765 articles were retrieved and after review, 44 articles (22 relating to PsV and 22 to PsA) met the systematic review's eligibility criteria. One study examined the response to methotrexate, one the response to tofacitinib and all the other studies to biologic disease-modifying antirheumatic drugs (DMARDs). Whilst several studies examined the HLA-C*06 allele in PsV, the results were conflicting. Interleukin (IL)-12 serum levels and polymorphisms in the IL-12B gene show promise as biomarkers of treatment response in PsV. Most, but not all, studies found that higher baseline levels of C-reactive protein (CRP) were associated with a better clinical response to treatment in patients with PsA. CONCLUSION: Several studies have identified biomarkers associated with subsequent response to treatment in psoriatic disease. However, due to the different types of biomarkers, treatments and outcome measures used, firm conclusions cannot be drawn. Further validation is needed before any of these biomarkers translate to clinical practice.

Description

Keywords

DMARD, biological therapy, drug response biomarkers, psoriasis, psoriatic arthritis, therapeutics

Journal Title

Ther Adv Musculoskelet Dis

Conference Name

Journal ISSN

1759-720X
1759-7218

Volume Title

13

Publisher

SAGE Publications
Sponsorship
National Institute for Health and Care Research (IS-BRC-1215-20014)