Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.

UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities. CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

Keywords

Development, Foetus, Insulin-like growth factor 1, Metabolism, Preterm infant, Animals, Fetal Development, Hormone Replacement Therapy, Humans, Infant, Newborn, Infant, Premature, Insulin-Like Growth Factor I

Journal Title

Acta Paediatr

Journal ISSN

0803-5253
1651-2227

Volume Title

105

Publisher

Wiley

Publisher DOI

https://doi.org/10.1111/apa.13350

Rights and licensing

Except where otherwised noted, this item's license is described as Attribution-NoDerivatives 4.0 International

Sponsorship

European Commission (305485)

This work was supported by a European Commission FP7 project 305485 PREVENT-ROP grant to all of the authors.

Collections

Scholarly Works - Paediatrics
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