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The exceptions that prove the rule-a historical view of bedaquiline susceptibility.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Miotto, Paolo 
Cirillo, Daniela M 
Schön, Thomas 

Abstract

In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results.

Description

Acknowledgements: T.S. is supported by the Heart and Lung Foundation (Oscar II Jubilee Foundation) and the Swedish Research Council. C.U.K. is a visiting scientist at the Department of Genetics, University of Cambridge, and a research associate at Wolfson College, University of Cambridge.

Keywords

Mycobacterium tuberculosis, Bedaquiline susceptibility, Clinical trials, Resistance mutations, Humans, Diarylquinolines, Antitubercular Agents, Mycobacterium tuberculosis, Mutation

Journal Title

Genome Med

Conference Name

Journal ISSN

1756-994X
1756-994X

Volume Title

16

Publisher

Springer Science and Business Media LLC