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TAp73 regulates ATP7A: possible implications for ageing-related diseases.

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cam.issuedOnline2018-12-08
dc.contributor.authorLopriore, Piervito
dc.contributor.authorCapitanio, Nazzareno
dc.contributor.authorPanatta, Emanuele
dc.contributor.authorDi Daniele, Nicola
dc.contributor.authorGambacurta, Alessandra
dc.contributor.authorMelino, Gerry
dc.contributor.authorAmelio, Ivano
dc.contributor.orcidMelino, Gerry [0000-0001-9428-5972]
dc.contributor.orcidAmelio, Ivano [0000-0002-9126-5391]
dc.date.accessioned2018-12-22T00:31:27Z
dc.date.available2018-12-22T00:31:27Z
dc.date.issued2018-12-08
dc.description.abstractThe p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its transcriptional signature and the extent of overlap with the other p53 family members is still missing. Here we describe a novel TAp73 target, ATP7A a member of a large family of P-type ATPases implicated in human neurogenerative conditions and cancer chemoresistance. Modulation of TAp73 expression influences basal expression level of ATP7A in different cellular models and chromatin immunoprecipitation confirmed a physical direct binding of TAp73 on ATP7A genomic regions. Bioinformatic analysis of expression profile datasets of human lung cancer patients suggests a possible implication of TAp73/ATP7A axis in human cancer. These data provide a novel TAp73-dependent target which might have implications in ageing-related diseases such as cancer and neurodegeneration.
dc.description.sponsorshipDepartment of Clinical & Experimental Medicine, University of Foggia, Italy 3 Department of Systems Medicine, Nephrology and Hypertension Unit, Tor Vergata University Hospital, Rome, Italy. 4 Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Italy
dc.format.mediumPrint
dc.identifier.doi10.17863/CAM.34707
dc.identifier.eissn1945-4589
dc.identifier.issn1945-4589
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287403
dc.languageeng
dc.language.isoeng
dc.publisherImpact Journals, LLC
dc.publisher.urlhttp://dx.doi.org/10.18632/aging.101669
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectageing
dc.subjectcancer
dc.subjectcopper
dc.subjectneurodegeneration
dc.subjectp53 family
dc.subjectAge Factors
dc.subjectAging
dc.subjectBinding Sites
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectCell Line, Tumor
dc.subjectCopper-Transporting ATPases
dc.subjectDatabases, Genetic
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectPromoter Regions, Genetic
dc.subjectSignal Transduction
dc.subjectTumor Protein p73
dc.titleTAp73 regulates ATP7A: possible implications for ageing-related diseases.
dc.typeArticle
dcterms.dateAccepted2018-11-15
prism.endingPage3760
prism.issueIdentifier12
prism.publicationDate2018
prism.publicationNameAging (Albany NY)
prism.startingPage3745
prism.volume10
rioxxterms.licenseref.startdate2018-12
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.18632/aging.101669

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