Deadly encounter: Endosomes meet Mitochondria to initiate Apoptosis
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Mitochondrial outer membrane permeabilization (MOMP) is a crucial event enabling apoptotic cell death. In this issue of Developmental Cell, Wang et al. reveal an interaction contributing to full MOMP execution, which depends on endosomes accumulating on apoptotic mitochondria. This causes mitochondrial lipid alterations that may contribute to functional pore assembly.
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Developmental Cell
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1534-5807
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Elsevier
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