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Ex situ-armus: experimental models for combating respiratory dysfunction.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Varankar, Sagar S 
Cardoso, Erik C 
Lee, Joo-Hyeon 

Abstract

Ex situ experimental models have become a main stay in pulmonary research. Organoids and explant systems have uncovered novel stem cell subsets, served as disease models, delineated cell fate transitions, and aided high throughput pre-clinical drug screening. Integration of gene-editing and bioengineering approaches have further generated novel avenues for regenerative medicine and transplantation strategies. In this article, we highlight recent studies, aided by ex situ systems, which have contributed to significant advances in our understanding of the human lower respiratory tract. We present key observations from these studies to gain improved insights into human disease. We conclude this article with a summary of existing challenges and potential technological advances to successfully mirror human tissue physiology.

Description

Keywords

Cell Differentiation, Humans, Models, Theoretical, Organoids, Regenerative Medicine, Stem Cells

Journal Title

Curr Opin Genet Dev

Conference Name

Journal ISSN

0959-437X
1879-0380

Volume Title

75

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (221857/Z/20/Z)
Medical Research Council (MC_PC_17230)