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Biomaterials and Fabrication to Optimise Scaffold Properties for Musculoskeletal Tissue Engineering.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Wheelton, Andrew 
Mace, James 
Khan, Wasim S 
Anand, Sanjay 

Abstract

Tissue engineering has emerged as a promising scientific field potentially yielding in vitro developed tissue to replace degenerative or injured tissues in vivo, thus avoiding the donor site morbidity associated with reconstructive surgery. Integral to the process is the role of scaffolds and the biomaterials used to form them. This review explores the concept of scaffold based tissue engineering and design considerations. The scaffold needs to have certain mechanical and architectural properties, it needs to be biocompatible and biodegradable, and allow combination with bioactive molecules. We also discuss scaffolding techniques, different biomaterial options and fabrication technologies, and future areas of development.

Description

Keywords

Biocompatible Materials, Humans, Musculoskeletal System, Tissue Engineering, Tissue Scaffolds

Journal Title

Curr Stem Cell Res Ther

Conference Name

Journal ISSN

1574-888X
2212-3946

Volume Title

11

Publisher

Bentham Science Publishers Ltd.