Repository logo
 

Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.

cam.issuedOnline2019-11-19
cam.orpheus.successThu Jan 30 10:36:46 GMT 2020 - Embargo updated
dc.contributor.authorReimann, Frank
dc.contributor.authorDiakogiannaki, Eleftheria
dc.contributor.authorHodge, Daryl
dc.contributor.authorGribble, Fiona M
dc.contributor.orcidReimann, Frank [0000-0001-9399-6377]
dc.contributor.orcidGribble, Fiona [0000-0002-4232-2898]
dc.date.accessioned2019-11-21T00:30:51Z
dc.date.available2019-11-21T00:30:51Z
dc.date.issued2020-03
dc.description.abstractGlucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted from the upper small intestine, which plays an important physiological role in the control of glucose metabolism through its incretin action to enhance glucose-dependent insulin secretion. GIP has also been implicated in postprandial lipid homeostasis. GIP is secreted from enteroendocrine K-cells residing in the intestinal epithelium. K-cells sense a variety of components found in the gut lumen following food consumption, resulting in an increase in plasma GIP signal dependent on the nature and quantity of ingested nutrients. We review the evidence for an important role of sodium-coupled glucose uptake through SGLT1 for carbohydrate sensing, of free-fatty acid receptors FFAR1/FFAR4 and the monoacyl-glycerol sensing receptor GPR119 for lipid detection, of the calcium-sensing receptor CASR and GPR142 for protein sensing, and additional modulation by neurotransmitters such as somatostatin and galanin. These pathways have been identified through combinations of in vivo, in vitro and molecular approaches.
dc.description.sponsorshipWellcome Trust BBSRC MRC
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.46159
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299097
dc.languageeng
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.peptides.2019.170206
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectGlucose-dependent insulinotropic polypeptide (GIP)
dc.subjectSecretion
dc.subjectEnteroendocrine Cells
dc.subjectGastric Inhibitory Polypeptide
dc.subjectGlucose
dc.subjectHumans
dc.subjectInsulin Secretion
dc.subjectReceptors, Calcium-Sensing
dc.subjectReceptors, G-Protein-Coupled
dc.subjectSodium-Glucose Transporter 1
dc.titleCellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.
dc.typeArticle
dcterms.dateAccepted2019-11-14
prism.publicationDate2020
prism.publicationNamePeptides
prism.startingPage170206
prism.volume125
pubs.funder-project-idWellcome Trust (084210/Z/07/Z)
pubs.funder-project-idWellcome Trust (084210/Z/07/A)
pubs.funder-project-idMedical Research Council (MC_UU_12012/3)
pubs.funder-project-idWellcome Trust (106262/Z/14/Z)
pubs.funder-project-idMRC (MC_UU_00014/3)
pubs.funder-project-idMRC (MC_UU_00014/5)
pubs.funder-project-idMedical Research Council (MC_PC_12012)
rioxxterms.licenseref.startdate2020-03
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.peptides.2019.170206

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
Reimann et al GIP secretion unmarked.docx
Size:
124.97 KB
Format:
Microsoft Word XML
Description:
Accepted version
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0/
No Thumbnail Available
Name:
figure.pptx
Size:
133.16 KB
Format:
Unknown data format
Description:
Supporting information
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0/
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
DepositLicenceAgreementv2.1.pdf
Size:
150.9 KB
Format:
Adobe Portable Document Format