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Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging.

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cam.issuedOnline2018-10-12
datacite.isderivedfrom.doi10.1101/264770
dc.contributor.authorFuhrmann, Delia
dc.contributor.authorNesbitt, David
dc.contributor.authorShafto, Meredith
dc.contributor.authorRowe, James B
dc.contributor.authorPrice, Darren
dc.contributor.authorGadie, Andrew
dc.contributor.authorCam-CAN
dc.contributor.authorKievit, Rogier A
dc.contributor.orcidFuhrmann, Delia [0000-0003-4678-8828]
dc.date.accessioned2018-12-08T00:30:22Z
dc.date.available2018-12-08T00:30:22Z
dc.date.issued2019-02
dc.description.abstractCardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort (N = 667, aged 18-88). We found that cardiovascular health and age made approximately similar contributions to white matter health and explained up to 56% of variance therein. Lower diastolic blood pressure, higher systolic blood pressure, and higher heart rate were each strongly, and independently, associated with white matter abnormalities on all indices. Body mass and exercise were associated with white matter health, both directly and indirectly via cardiovascular health. These results highlight the importance of cardiovascular risk factors for white matter health across the adult lifespan and suggest that systolic blood pressure, diastolic blood pressure, and heart rate affect white matter health via separate mechanisms.
dc.description.sponsorshipDF, DN, JBR, DP and RAK are supported by the UK Medical Research Council. The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1). RAK is supported by the Sir Henry Wellcome Trust (grant number 107392/Z/15/Z) and MRC Programme Grant MC-A060-5PR60. This project has also received funding from the European Union’s Horizon 2020 research and innovation programme (grant agreement number 732592).
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.33815
dc.identifier.eissn1558-1497
dc.identifier.issn0197-4580
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286505
dc.languageeng
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.10.005
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAging
dc.subjectBlood pressure
dc.subjectCardiovascular health
dc.subjectDiffusion weighted imaging
dc.subjectHeart rate
dc.subjectWhite matter lesion
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBlood Pressure
dc.subjectBody Mass Index
dc.subjectCardiovascular Diseases
dc.subjectCohort Studies
dc.subjectCross-Sectional Studies
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectExercise
dc.subjectFemale
dc.subjectHealthy Aging
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.subjectWhite Matter
dc.subjectYoung Adult
dc.titleStrong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging.
dc.typeArticle
dcterms.dateAccepted2018-10-04
prism.endingPage55
prism.publicationDate2019
prism.publicationNameNeurobiol Aging
prism.startingPage46
prism.volume74
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idEuropean Commission (732592)
pubs.funder-project-idMRC (Unknown)
pubs.funder-project-idMedical Research Council (G0500842)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/H008217/1)
pubs.funder-project-idWellcome Trust (107392/Z/15/Z)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idMedical Research Council (MC_UP_1401/1)
pubs.funder-project-idMedical Research Council (MC_UU_00005/9)
pubs.funder-project-idMedical Research Council (MC_UU_00005/12)
rioxxterms.licenseref.startdate2019-02
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.neurobiolaging.2018.10.005

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