Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease.

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Sheikh-Bahaei, Nasim  ORCID logo
Sajjadi, S Ahmad 
Priest, Andrew N 
O'Brien, John T 

BACKGROUND: Despite the well-documented relationship between lobar cerebral microbleeds (lCMB) and Alzheimer's disease (AD), there is limited knowledge about the role of lCMB in AD pathology. OBJECTIVE: To understand the nature of this relationship, we investigated the association between lCMB, amyloid load, perfusion, and metabolism. METHODS: Participants with AD, mild cognitive impairment (MCI), and healthy controls were recruited and scanned with 11C-Pittsburg-Compound B (PiB), Fluorodeoxyglucose (FDG) PET, and susceptibility-weighted MRI. Early PiB-PET frames were used to estimate perfusion. The association between lCMB and PET uptake in each anatomical lobe was measured using multiple regression models. RESULTS: The presence of lCMB predicted increased total (p < 0.001) and regional (p = 0.0002) PiB uptake, as well as decreased cerebral perfusion (p = 0.03). Cases with lCMB had hypometabolism in their temporal lobe (p = 0.04). CONCLUSION: There are significant relationships between lCMBs and various markers of AD pathology. lCMB has a spatial association with Aβ load and a complex effect on perfusion and metabolism.

Alzheimer’s disease, FDG-PET, PiB-PET, cerebral metabolism, cerebral perfusion, lobar cerebral microbleeds, susceptibility weighted imaging, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Brain, Cerebral Hemorrhage, Cognitive Dysfunction, Female, Fluorodeoxyglucose F18, Humans, Magnetic Resonance Imaging, Male, Positron-Emission Tomography
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J Alzheimers Dis
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IOS Press
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Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)