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Translational tests involving non-reward: methodological considerations.

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cam.issuedOnline2018-10-10
dc.contributor.authorPhillips, Benjamin U
dc.contributor.authorLopez-Cruz, Laura
dc.contributor.authorSaksida, Lisa M
dc.contributor.authorBussey, Timothy J
dc.contributor.orcidPhillips, Benjamin U [0000-0002-3680-8197]
dc.date.accessioned2019-01-15T00:30:45Z
dc.date.available2019-01-15T00:30:45Z
dc.date.issued2019-01
dc.description.abstractThis review is concerned with methods for assessing the processing of unrewarded responses in experimental animals and the mechanisms underlying performance of these tasks. A number of clinical populations, including Parkinson's disease, depression, compulsive disorders, and schizophrenia demonstrate either abnormal processing or learning from non-rewarded responses in laboratory-based reinforcement learning tasks. These effects are hypothesized to result from disturbances in modulatory neurotransmitter systems, including dopamine and serotonin. Parallel work in experimental animals has revealed consistent behavioral patterns associated with non-reward and, consistent with the human literature, modulatory roles for specific neurotransmitters. Classical tests involving an important reward omission component include appetitive extinction, ratio schedules of responding, reversal learning, and delay and probability discounting procedures. In addition, innovative behavioral tests have recently been developed leverage probabilistic feedback to specifically assay accommodation of, and learning from, non-rewarded responses. These procedures will be described and reviewed with discussion of the behavioral and neural determinants of performance. A final section focusses specifically on the benefits of trial-by-trial analysis of responding during such tasks, and the implications of such analyses for the translation of findings to clinical studies.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.35294
dc.identifier.eissn1432-2072
dc.identifier.issn0033-3158
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287974
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s00213-018-5062-x
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDopamine
dc.subjectExtinction
dc.subjectLearning
dc.subjectOperant
dc.subjectSchedules of reinforcement
dc.subjectSerotonin
dc.subjectTouchscreen
dc.subjectAnimals
dc.subjectAssociation Learning
dc.subjectBrain
dc.subjectConditioning, Classical
dc.subjectConditioning, Operant
dc.subjectDelay Discounting
dc.subjectDisease Models, Animal
dc.subjectDopamine
dc.subjectHumans
dc.subjectMale
dc.subjectMotivation
dc.subjectNeurotransmitter Agents
dc.subjectReinforcement, Psychology
dc.subjectReversal Learning
dc.subjectReward
dc.subjectSchizophrenia
dc.subjectSchizophrenic Psychology
dc.subjectSerotonin
dc.subjectTranslational Research, Biomedical
dc.titleTranslational tests involving non-reward: methodological considerations.
dc.typeArticle
dcterms.dateAccepted2018-10-02
prism.endingPage461
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNamePsychopharmacology (Berl)
prism.startingPage449
prism.volume236
rioxxterms.licenseref.startdate2019-01
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s00213-018-5062-x

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