Repository logo
 

Translational Research in Intensive Care Unit: Novel Approaches for Drug Development and Personalized Medicine.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Samanta, Romit J 

Abstract

The major clinical presentations seen by critical care physicians are sepsis and acute respiratory distress syndrome (ARDS), both of which are heterogeneous clinical syndromes rather than specific diagnoses. The current diagnostic criteria provide little insight into the mechanisms underlying these heterogeneous syndromes and minimal progress has been made with regard to the development of therapies, despite many large randomized controlled trials being undertaken. This review outlines the advances made in improved characterization of critically-ill patients, using ARDS as an exemplar, and highlights the need for this improved patient characterization to be coupled with mechanistic science to develop therapies that target specific pathomechanisms.

Description

Keywords

Critical Care, Critical Illness, Drug Development, Humans, Intensive Care Units, Precision Medicine, Randomized Controlled Trials as Topic, Respiratory Distress Syndrome, Sepsis, Translational Research, Biomedical

Journal Title

Semin Respir Crit Care Med

Conference Name

Journal ISSN

1069-3424
1098-9048

Volume Title

40

Publisher

Thieme

Rights

All rights reserved
Sponsorship
Medical Research Council (MR/P502091/1)