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Down Syndrome Biobank Consortium: A perspective.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Aldecoa, Iban 
Barroeta, Isabel 
Carroll, Steven L 
Fortea, Juan 
Gilmore, Anah 

Abstract

Individuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset Alzheimer's disease (AD)-type dementia by early midlife. Despite ongoing clinical trials to treat late-onset AD, individuals with DS are often excluded. Furthermore, timely diagnosis or management is often not available. Of the genetic causes of AD, people with DS represent the largest cohort. Currently, there is a knowledge gap regarding the underlying neurobiological mechanisms of DS-related AD (DS-AD), partly due to limited access to well-characterized brain tissue and biomaterials for research. To address this challenge, we created an international consortium of brain banks focused on collecting and disseminating brain tissue from persons with DS throughout their lifespan, named the Down Syndrome Biobank Consortium (DSBC) consisting of 11 biobanking sites located in Europe, India, and the USA. This perspective describes the DSBC harmonized protocols and tissue dissemination goals.

Description

Publication status: Published


Funder: Barrow Neurological Foundation; doi: http://dx.doi.org/10.13039/100009797


Funder: Fein Foundation


Funder: Arizona Alzheimer's Consortium

Keywords

Alzheimer's disease, Down syndrome, biobanking, brain banking, repository, research, Humans, Down Syndrome, Biological Specimen Banks, Alzheimer Disease, Brain, Europe

Journal Title

Alzheimers Dement

Conference Name

Journal ISSN

1552-5260
1552-5279

Volume Title

Publisher

Wiley
Sponsorship
NIH (R01AG071228, R01AG070153, R01AG061566, P01AG060882, P30AG066512)
NIH/NIA (P30AG066519, U19AG068054, P01AG014449, RF1AG077103, R01AG074004, RF1AG061566, RF1AG081286, AG017617)
BrightFocus Foundation (CA2018010)