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Comparative quasi-static mechanical characterization of fresh and stored porcine trachea specimens

Published version
Peer-reviewed

Type

Article

Change log

Authors

Butler, BJ 
Tucker, AW 
Proud, WG 
Brown, KA 

Abstract

Abstract: Tissues of the upper airways of critically ill patients are particularly vulnerable to mechanical damage associated with the use of ventilators. Ventilation is known to disrupt the structural integrity of respiratory tissues and their function. This damage contributes to the vulnerability of these tissues to infection. We are currently developing tissue models of damage and infection to the upper airways. As part of our studies, we have compared how tissue storage conditions affect mechanical properties of excised respiratory tissues using a quasi-static platform. Data presented here show considerable differences in mechanical responses of stored specimens compared to freshly excised specimens. These data indicate that implementation of storage and maintenance procedures that minimize rapid degradation of tissue structure are essential for retaining the material properties in our tissue trauma models.

Description

Keywords

49 Mathematical Sciences, 51 Physical Sciences

Journal Title

European Physical Journal: Special Topics

Conference Name

Journal ISSN

1951-6355
1951-6401

Volume Title

227

Publisher

Springer Science and Business Media LLC
Sponsorship
Royal British Legion (RBL) (via Imperial College London) (PH/2860260)
Isaac Newton Trust (1540(u))