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SERS Sensing of Dopamine with Fe(III)-Sensitized Nanogaps in Recleanable AuNP Monolayer Films.

Accepted version
Peer-reviewed

Type

Article

Change log

Abstract

Sensing of neurotransmitters (NTs) down to nm concentrations is demonstrated by utilizing self-assembled monolayers of plasmonic 60 nm Au nanoparticles in close-packed arrays immobilized onto glass substrates. Multiplicative surface-enhanced Raman spectroscopy enhancements are achieved by integrating Fe(III) sensitizers into the precisely-defined <1 nm nanogaps, to target dopamine (DA) sensing. The transparent glass substrates allow for efficient access from both sides of the monolayer aggregate films by fluid and light, allowing repeated sensing in different analytes. Repeated reusability after analyte sensing is shown through oxygen plasma cleaning protocols, which restore pristine conditions for the nanogaps. Examining binding competition in multiplexed sensing of two catecholamine NTs, DA and epinephrine, reveals their bidentate binding and their interactions. These systems are promising for widespread microfluidic integration enabling a wide range of continuous biofluid monitoring for applications in precision health.

Description

Keywords

Au nanoparticles, Fe(III)-sensitization, cleaning, dopamine, multiplex, sensing, surface-enhanced Raman spectroscopy

Journal Title

Small

Conference Name

Journal ISSN

1613-6810
1613-6829

Volume Title

Publisher

Wiley
Sponsorship
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (829067)
European Commission Horizon 2020 (H2020) ERC (883703)
European Commission Horizon 2020 (H2020) Research Infrastructures (RI) (861950)
Engineering and Physical Sciences Research Council (EP/L015978/1)
Engineering and Physical Sciences Research Council (EP/L027151/1)
Royal Society (URF\R1\211162)
Engineering and Physical Sciences Research Council (EP/R020965/1)
Engineering and Physical Sciences Research Council (EP/P024947/1)
Engineering and Physical Sciences Research Council (EP/R00661X/1)