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A genomic history of Aboriginal Australia.

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cam.issuedOnline2016-09-21
dc.contributor.authorMalaspinas, Anna-Sapfo
dc.contributor.authorWestaway, Michael C
dc.contributor.authorMuller, Craig
dc.contributor.authorSousa, Vitor C
dc.contributor.authorLao, Oscar
dc.contributor.authorAlves, Isabel
dc.contributor.authorBergström, Anders
dc.contributor.authorAthanasiadis, Georgios
dc.contributor.authorCheng, Jade Y
dc.contributor.authorCrawford, Jacob E
dc.contributor.authorHeupink, Tim H
dc.contributor.authorMacholdt, Enrico
dc.contributor.authorPeischl, Stephan
dc.contributor.authorRasmussen, Simon
dc.contributor.authorSchiffels, Stephan
dc.contributor.authorSubramanian, Sankar
dc.contributor.authorWright, Joanne L
dc.contributor.authorAlbrechtsen, Anders
dc.contributor.authorBarbieri, Chiara
dc.contributor.authorDupanloup, Isabelle
dc.contributor.authorEriksson, Anders
dc.contributor.authorMargaryan, Ashot
dc.contributor.authorMoltke, Ida
dc.contributor.authorPugach, Irina
dc.contributor.authorKorneliussen, Thorfinn S
dc.contributor.authorLevkivskyi, Ivan P
dc.contributor.authorMoreno-Mayar, J Víctor
dc.contributor.authorNi, Shengyu
dc.contributor.authorRacimo, Fernando
dc.contributor.authorSikora, Martin
dc.contributor.authorXue, Yali
dc.contributor.authorAghakhanian, Farhang A
dc.contributor.authorBrucato, Nicolas
dc.contributor.authorBrunak, Søren
dc.contributor.authorCampos, Paula F
dc.contributor.authorClark, Warren
dc.contributor.authorEllingvåg, Sturla
dc.contributor.authorFourmile, Gudjugudju
dc.contributor.authorGerbault, Pascale
dc.contributor.authorInjie, Darren
dc.contributor.authorKoki, George
dc.contributor.authorLeavesley, Matthew
dc.contributor.authorLogan, Betty
dc.contributor.authorLynch, Aubrey
dc.contributor.authorMatisoo-Smith, Elizabeth A
dc.contributor.authorMcAllister, Peter J
dc.contributor.authorMentzer, Alexander J
dc.contributor.authorMetspalu, Mait
dc.contributor.authorMigliano, Andrea B
dc.contributor.authorMurgha, Les
dc.contributor.authorPhipps, Maude E
dc.contributor.authorPomat, William
dc.contributor.authorReynolds, Doc
dc.contributor.authorRicaut, Francois-Xavier
dc.contributor.authorSiba, Peter
dc.contributor.authorThomas, Mark G
dc.contributor.authorWales, Thomas
dc.contributor.authorWall, Colleen Ma'run
dc.contributor.authorOppenheimer, Stephen J
dc.contributor.authorTyler-Smith, Chris
dc.contributor.authorDurbin, Richard
dc.contributor.authorDortch, Joe
dc.contributor.authorManica, Andrea
dc.contributor.authorSchierup, Mikkel H
dc.contributor.authorFoley, Robert A
dc.contributor.authorLahr, Marta Mirazón
dc.contributor.authorBowern, Claire
dc.contributor.authorWall, Jeffrey D
dc.contributor.authorMailund, Thomas
dc.contributor.authorStoneking, Mark
dc.contributor.authorNielsen, Rasmus
dc.contributor.authorSandhu, Manjinder S
dc.contributor.authorExcoffier, Laurent
dc.contributor.authorLambert, David M
dc.contributor.authorWillerslev, Eske
dc.contributor.orcidEriksson, Anders [0000-0003-3436-3726]
dc.contributor.orcidDurbin, Richard [0000-0002-9130-1006]
dc.contributor.orcidManica, Andrea [0000-0003-1895-450X]
dc.contributor.orcidFoley, Robert [0000-0003-0479-3039]
dc.contributor.orcidMirazon Lahr, Marta [0000-0001-5752-5770]
dc.contributor.orcidSandhu, Manjinder [0000-0002-2725-142X]
dc.contributor.orcidWillerslev, Eske [0000-0002-7081-6748]
dc.date.accessioned2018-09-29T06:09:02Z
dc.date.available2018-09-29T06:09:02Z
dc.date.issued2016-10-13
dc.description.abstractThe population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama-Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25-40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australians descend from a single founding population that differentiated ~10-32 kya. We infer a population expansion in northeast Australia during the Holocene epoch (past 10,000 years) associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama-Nyungan languages. We estimate that Aboriginal Australians and Papuans diverged from Eurasians 51-72 kya, following a single out-of-Africa dispersal, and subsequently admixed with archaic populations. Finally, we report evidence of selection in Aboriginal Australians potentially associated with living in the desert.
dc.identifier.doi10.17863/CAM.30300
dc.identifier.eissn1476-4687
dc.identifier.issn0028-0836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282937
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/nature18299
dc.subjectAfrica
dc.subjectAustralia
dc.subjectDatasets as Topic
dc.subjectDesert Climate
dc.subjectGene Flow
dc.subjectGenetics, Population
dc.subjectGenome, Human
dc.subjectGenomics
dc.subjectHistory, Ancient
dc.subjectHuman Migration
dc.subjectHumans
dc.subjectLanguage
dc.subjectNative Hawaiian or Other Pacific Islander
dc.subjectNew Guinea
dc.subjectPhylogeny
dc.subjectPopulation Dynamics
dc.subjectRacial Groups
dc.subjectTasmania
dc.titleA genomic history of Aboriginal Australia.
dc.typeArticle
dcterms.dateAccepted2016-05-04
prism.issueIdentifier7624
prism.publicationDate2016
prism.publicationNameNature
prism.volume538
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/H005854/1)
pubs.funder-project-idEuropean Research Council (647787)
pubs.funder-project-idEuropean Research Council (295907)
rioxxterms.licenseref.startdate2016-10-13
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1038/nature18299

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