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Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations.

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Fletcher, Paul 
Mallucci, Conor 
Avula, Shivaram 
Ajithkumar, Thankamma 


The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment. As the lesion itself, as well as each treatment, can cause specific neural damage, the long-term neurocognitive outcomes are highly complex and challenging to assess. The number of neurocognitive studies in this population grows exponentially worldwide, motivating modern neuroscience to provide guidance in follow-up before, during and after treatment. In this review, we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor types. Based on this information, we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.


Acknowledgements: During the literature review phase, C.S. was funded by the Fonds voor Wetenschappelijk Onderzoek for a senior post-doctoral fellowship. PCF is supported by funding from the Bernard Wolfe Health Neuroscience Fund (206368/Z/17/Z). His research is also supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014).


Connectome, Neurocognition, Neuroimaging, Neuropsychological assessment, Pediatric brain tumor, Child, Humans, Brain, Brain Neoplasms, Cognitive Dysfunction, Connectome, Neurosciences

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Neurosci Bull

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Springer Science and Business Media LLC
National Institute for Health and Care Research (IS-BRC-1215-20014)