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Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations.

Published version
Peer-reviewed

Repository DOI


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Authors

Fletcher, Paul 
Mallucci, Conor 
Avula, Shivaram 
Ajithkumar, Thankamma 

Abstract

The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment. As the lesion itself, as well as each treatment, can cause specific neural damage, the long-term neurocognitive outcomes are highly complex and challenging to assess. The number of neurocognitive studies in this population grows exponentially worldwide, motivating modern neuroscience to provide guidance in follow-up before, during and after treatment. In this review, we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor types. Based on this information, we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.

Description

Acknowledgements: During the literature review phase, C.S. was funded by the Fonds voor Wetenschappelijk Onderzoek for a senior post-doctoral fellowship. PCF is supported by funding from the Bernard Wolfe Health Neuroscience Fund (206368/Z/17/Z). His research is also supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014).

Keywords

Connectome, Neurocognition, Neuroimaging, Neuropsychological assessment, Pediatric brain tumor, Child, Humans, Brain, Brain Neoplasms, Cognitive Dysfunction, Connectome, Neurosciences

Journal Title

Neurosci Bull

Conference Name

Journal ISSN

1673-7067
1995-8218

Volume Title

39

Publisher

Springer Science and Business Media LLC
Sponsorship
National Institute for Health and Care Research (IS-BRC-1215-20014)