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Insights into human genetic variation and population history from 929 diverse genomes.

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Genome sequences from diverse human groups are needed to understand the structure of genetic variation in our species and the history of, and relationships between, different populations. We present 929 high-coverage genome sequences from 54 diverse human populations, 26 of which are physically phased using linked-read sequencing. Analyses of these genomes reveal an excess of previously undocumented common genetic variation private to southern Africa, central Africa, Oceania, and the Americas, but an absence of such variants fixed between major geographical regions. We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and agriculturalist groups in the past 10,000 years, and a contrast between single Neanderthal but multiple Denisovan source populations contributing to present-day human populations.



Africa, Americas, Animals, Asia, DNA Copy Number Variations, Genetic Variation, Genetics, Population, Genome, Human, Haplotypes, Hominidae, Humans, INDEL Mutation, Neanderthals, Oceania, Phylogeny, Polymorphism, Single Nucleotide, Population Density, Racial Groups, Whole Genome Sequencing

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American Association for the Advancement of Science (AAAS)


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Wellcome Trust (unknown)
Wellcome Trust Sanger Institute, Genome Research Limited (S0818)
Wellcome grants 098051 and 206194, and S.A.M. and R.D. also by Wellcome grant 207492. A.B. and P.S. were supported by the Francis Crick Institute (FC001595) which receives its core funding from Cancer Research UK, the UK Medical Research Council and the Wellcome Trust. P.S. was also supported by the European Research Council (grant no. 852558) and the Wellcome Trust (217223/Z/19/Z). R.H. was supported by a Gates Cambridge scholarship. P.H. was supported by Estonian Research Council Grant PUT1036. D.R. is an Investigator of the Howard Hughes Medical Institute.
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