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Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners.

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cam.issuedOnline2018-09-19
dc.contributor.authorCarlyon, Robert P
dc.contributor.authorDeeks, John M
dc.contributor.authorGuérit, François
dc.contributor.authorLamping, Wiebke
dc.contributor.authorBillig, Alexander J
dc.contributor.authorLarge, Charles H
dc.contributor.authorSaeed, Shakeel R
dc.contributor.authorHarris, Peter
dc.contributor.orcidCarlyon, Robert P [0000-0002-6166-501X]
dc.date.accessioned2018-11-20T00:30:17Z
dc.date.available2018-11-20T00:30:17Z
dc.date.issued2018-12
dc.description.abstractTemporal processing by cochlear implant listeners is degraded and is affected by auditory deprivation. The fast-acting Kv3.1 potassium channel is important for sustained temporally accurate firing and is also susceptible to deprivation, the effects of which can be partially restored in animals by the molecule AUT00063. We report the results of a randomised placebo-controlled double-blind study on psychophysical tests of the effects of AUT00063 on temporal processing by CI listeners. The study measured the upper limit of temporal pitch, gap detection, and discrimination of low rates (centred on 120 pps) for monopolar pulse trains presented to an apical electrode. The upper limit was measured using the optimally efficient midpoint comparison (MPC) pitch-ranking procedure; thresholds were obtained for the other two measures using an adaptive procedure. Twelve CI users (MedEl and Cochlear) were tested before and after two periods of AUT00063 or placebo in a within-subject crossover study. No significant differences occurred between post-drug and post-placebo conditions. This absence of effect occurred despite high test-retest reliability for all three measures, obtained by comparing performance on the two baseline visits, and despite the demonstrated sensitivity of the measures to modest changes in temporal processing obtained in other studies from our laboratory. Hence, we have no evidence that AUT00063 improves temporal processing for the doses and patient population employed.
dc.description.sponsorshipAutifony therapeutics
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.32794
dc.identifier.eissn1438-7573
dc.identifier.issn1525-3961
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285434
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s10162-018-00694-z
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAUT00063
dc.subjectcochlear implant (CI)
dc.subjectgap detection threshold (GDT)
dc.subjectkv3.1
dc.subjectmidpoint comparison procedure (MPC)
dc.subjectrate discrimination ratio (RDR)
dc.subjecttemporal processing
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAuditory Perception
dc.subjectCochlear Implants
dc.subjectCross-Over Studies
dc.subjectDeafness
dc.subjectDouble-Blind Method
dc.subjectHearing Tests
dc.subjectHumans
dc.subjectImidazoles
dc.subjectMiddle Aged
dc.subjectPyrimidines
dc.subjectShaw Potassium Channels
dc.titleEvaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners.
dc.typeArticle
dcterms.dateAccepted2018-07-16
prism.endingPage680
prism.issueIdentifier6
prism.publicationDate2018
prism.publicationNameJ Assoc Res Otolaryngol
prism.startingPage669
prism.volume19
pubs.funder-project-idMedical Research Council (MC_UU_00005/3)
rioxxterms.licenseref.startdate2018-12
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s10162-018-00694-z

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