cam.issuedOnline	2014-07-28
dc.contributor.author	Lawson, Rebecca P
dc.contributor.author	Seymour, Ben
dc.contributor.author	Loh, Eleanor
dc.contributor.author	Lutti, Antoine
dc.contributor.author	Dolan, Raymond J
dc.contributor.author	Dayan, Peter
dc.contributor.author	Weiskopf, Nikolaus
dc.contributor.author	Roiser, Jonathan P
dc.contributor.orcid	Lawson, Rebecca [0000-0003-1228-1244]
dc.contributor.orcid	Seymour, Benjamin [0000-0003-1724-5832]
dc.date.accessioned	2019-05-08T14:08:51Z
dc.date.available	2019-05-08T14:08:51Z
dc.date.issued	2014-08-12
dc.description.abstract	Learning what to approach, and what to avoid, involves assigning value to environmental cues that predict positive and negative events. Studies in animals indicate that the lateral habenula encodes the previously learned negative motivational value of stimuli. However, involvement of the habenula in dynamic trial-by-trial aversive learning has not been assessed, and the functional role of this structure in humans remains poorly characterized, in part, due to its small size. Using high-resolution functional neuroimaging and computational modeling of reinforcement learning, we demonstrate positive habenula responses to the dynamically changing values of cues signaling painful electric shocks, which predict behavioral suppression of responses to those cues across individuals. By contrast, negative habenula responses to monetary reward cue values predict behavioral invigoration. Our findings show that the habenula plays a key role in an online aversive learning system and in generating associated motivated behavior in humans.
dc.format.medium	Print-Electronic
dc.identifier.doi	10.17863/CAM.39696
dc.identifier.eissn	1091-6490
dc.identifier.issn	0027-8424
dc.identifier.uri	https://www.repository.cam.ac.uk/handle/1810/292537
dc.language	eng
dc.language.iso	eng
dc.publisher	Proceedings of the National Academy of Sciences
dc.publisher.url	http://dx.doi.org/10.1073/pnas.1323586111
dc.subject	conditioned behavior
dc.subject	high-resolution fMRI
dc.subject	pallidum
dc.subject	Adult
dc.subject	Animals
dc.subject	Conditioning, Psychological
dc.subject	Cues
dc.subject	Female
dc.subject	Functional Neuroimaging
dc.subject	Habenula
dc.subject	Humans
dc.subject	Learning
dc.subject	Magnetic Resonance Imaging
dc.subject	Male
dc.subject	Motivation
dc.subject	Punishment
dc.subject	Reinforcement, Psychology
dc.subject	Species Specificity
dc.subject	Young Adult
dc.title	The habenula encodes negative motivational value associated with primary punishment in humans.
dc.type	Article
prism.endingPage	11863
prism.issueIdentifier	32
prism.publicationDate	2014
prism.publicationName	Proc Natl Acad Sci U S A
prism.startingPage	11858
prism.volume	111
rioxxterms.licenseref.startdate	2014-08
rioxxterms.licenseref.uri	http://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.type	Journal Article/Review
rioxxterms.version	AM
rioxxterms.versionofrecord	10.1073/pnas.1323586111

The habenula encodes negative motivational value associated with primary punishment in humans.

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