Weaving Causal Explanations of Schizophrenia in Urban Areas: The Role of Gene-Environment Selection.


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Type
Article
Change log
Authors
Jongsma, Hannah E 
Jones, Peter B 
Abstract

Schizophrenia has long been reported to be more common in urban areas, although recent research suggests this association may not occur in low- and middle-income countries. Explanations of this urbanicity association, entwined with links between the disorder and socioeconomic deprivation, have led people to question the possibilities of a reverse causal association: do people with early illness or strong liability drift into cities and down the social scale, or do those environments exert a toxic effect? Few studies dissect city life from a socioenvironmental context4 but urbanicity certainly is associated with cognition and the brain. Evidence is also emerging that part of the liability to living in deprived neighborhoods is associated with genetics; it is heritable, and, moreover, genes conferring liability to schizophrenia may be particularly involved.

Description
Keywords
Humans, Population Density, Risk Factors, Schizophrenia
Journal Title
JAMA Psychiatry
Conference Name
Journal ISSN
2168-622X
2168-6238
Volume Title
75
Publisher
American Medical Association (AMA)