Weaving Causal Explanations of Schizophrenia in Urban Areas: The Role of Gene-Environment Selection.
| cam.issuedOnline | 2018-06-23 | |
| dc.contributor.author | Jongsma, Hannah E | |
| dc.contributor.author | Jones, Peter B | |
| dc.contributor.orcid | Jongsma, Hannah [0000-0001-6346-5903] | |
| dc.contributor.orcid | Jones, Peter [0000-0002-0387-880X] | |
| dc.date.accessioned | 2018-09-11T07:58:20Z | |
| dc.date.available | 2018-09-11T07:58:20Z | |
| dc.date.issued | 2018-09-01 | |
| dc.description.abstract | Schizophrenia has long been reported to be more common in urban areas, although recent research suggests this association may not occur in low- and middle-income countries. Explanations of this urbanicity association, entwined with links between the disorder and socioeconomic deprivation, have led people to question the possibilities of a reverse causal association: do people with early illness or strong liability drift into cities and down the social scale, or do those environments exert a toxic effect? Few studies dissect city life from a socioenvironmental context4 but urbanicity certainly is associated with cognition and the brain. Evidence is also emerging that part of the liability to living in deprived neighborhoods is associated with genetics; it is heritable, and, moreover, genes conferring liability to schizophrenia may be particularly involved. | |
| dc.format.medium | ||
| dc.identifier.doi | 10.17863/CAM.27480 | |
| dc.identifier.eissn | 2168-6238 | |
| dc.identifier.issn | 2168-622X | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/280115 | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | American Medical Association (AMA) | |
| dc.publisher.url | http://dx.doi.org/10.1001/jamapsychiatry.2018.1795 | |
| dc.subject | Humans | |
| dc.subject | Population Density | |
| dc.subject | Risk Factors | |
| dc.subject | Schizophrenia | |
| dc.title | Weaving Causal Explanations of Schizophrenia in Urban Areas: The Role of Gene-Environment Selection. | |
| dc.type | Article | |
| prism.endingPage | 880 | |
| prism.issueIdentifier | 9 | |
| prism.publicationDate | 2018 | |
| prism.publicationName | JAMA Psychiatry | |
| prism.startingPage | 878 | |
| prism.volume | 75 | |
| rioxxterms.licenseref.startdate | 2018-09 | |
| rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1001/jamapsychiatry.2018.1795 |
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