The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology.
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Peer-reviewed
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Abstract
Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and cytosol. An increasing number of diseases and pathologies has been associated with their dysfunction. In this review, the molecular basis of these diseases is explained based on our current understanding of their transport mechanism.
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Keywords
bioenergetics, impaired transport mechanism, mitochondrial disease, mitochondrial physiology, pathological mutations, Animals, Biological Transport, Energy Metabolism, Humans, Mitochondria, Mitochondrial Diseases, Mitochondrial Membranes, Mitochondrial Proteins, Mutation, Missense, Organic Anion Transporters
Journal Title
Physiology (Bethesda)
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1548-9213
1548-9221
1548-9221
Volume Title
35
Publisher
American Physiological Society
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Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Medical Research Council (MC_UU_00015/1)
Medical Research Council (MC_UU_00015/7)
Medical Research Council (MC_UU_00015/7)