Cleavable linkers in antibody–drug conjugates

Cleavable linkers in antibody–drug conjugates

Accepted version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/294617

Files

Accepted version (5.55 MB)

Type

Authors

Bargh, Jonathan D

Isidro-Llobet, Albert

Parker, Jeremy S

Spring, David R

Abstract

This tutorial review summarises the advances in the field of cleavable linker technologies for antibody–drug conjugates (ADCs).

Keywords

Acids, Animals, Antibodies, Monoclonal, Antineoplastic Agents, Cathepsin B, Disulfides, Drug Stability, Humans, Immunoconjugates

Journal Title

Chemical Society Reviews

Journal ISSN

0306-0012
1460-4744

Publisher

Royal Society of Chemistry (RSC)

Publisher DOI

https://doi.org/10.1039/c8cs00676h

Rights and licensing

Except where otherwised noted, this item's license is described as http://www.rioxx.net/licenses/all-rights-reserved

Sponsorship

Engineering and Physical Sciences Research Council (1800455)

Collections

University of Cambridge Research Outputs (Articles and Conferences)