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Paradoxical pharmacological dissociations result from drugs that enhance delta oscillations but preserve consciousness.

Published version
Peer-reviewed

Repository DOI


Type

Article

Change log

Authors

Mediano, Pedro AM 
Bavato, Francesco 
Gharabaghi, Alireza 

Abstract

Low-frequency (<4 Hz) neural activity, particularly in the delta band, is generally indicative of loss of consciousness and cortical down states, particularly when it is diffuse and high amplitude. Remarkably, however, drug challenge studies of several diverse classes of pharmacological agents-including drugs which treat epilepsy, activate GABAB receptors, block acetylcholine receptors, or produce psychedelic effects-demonstrate neural activity resembling cortical down states even as the participants remain conscious. Of those substances that are safe to use in healthy volunteers, some may be highly valuable research tools for investigating which neural activity patterns are sufficient for consciousness or its absence.

Description

Funder: University of Tuebingen Open Access Publishing Fund

Keywords

Humans, Consciousness, Epilepsy

Journal Title

Commun Biol

Conference Name

Journal ISSN

2399-3642
2399-3642

Volume Title

6

Publisher

Springer Science and Business Media LLC