Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan.
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Peer-reviewed
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Abstract
Klebsiella pneumoniae shows increasing emergence of multidrug-resistant lineages, including strains resistant to all available antimicrobial drugs. We conducted whole-genome sequencing of 178 highly drug-resistant isolates from a tertiary hospital in Lahore, Pakistan. Phylogenetic analyses to place these isolates into global context demonstrate the expansion of multiple independent lineages, including K. quasipneumoniae.
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Keywords
Australia, ESBL, Klebsiella, Klebsiella pneumonia, Pakistan, United Kingdom, antimicrobial resistance, bacteria, children, extended-spectrum β-lactamase, multidrug resistance, neonatal infection, Adolescent, Anti-Bacterial Agents, Child, Child, Hospitalized, Child, Preschool, Drug Resistance, Multiple, Bacterial, Genome, Bacterial, Humans, Infant, Infant, Newborn, Klebsiella Infections, Klebsiella pneumoniae, Pakistan, Phylogeny, Sequence Analysis, DNA
Journal Title
Emerg Infect Dis
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1080-6040
1080-6059
1080-6059
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23
Publisher
Centers for Disease Control and Prevention
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Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
National Health and Medical Research Council (1092262)
National Health and Medical Research Council (1092262)
This work was supported by National Health and Medical Research Council program grants (0606788 to R.A.S. and T. L.; 1092262 to R.A.S., G.D., and T.L.); the Wellcome Trust (206194); and the Higher Education Commission of Pakistan and The Children’s Hospital & The Institute of Child Health, Lahore, Pakistan. H.E. was supported by a scholarship from Higher Education Commission Pakistan under the International Research Support Initiative Program.