Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis.


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Article
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Abstract

Pulse pressure (PP), the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), arises due to pulsatile ejection of blood from the left ventricle. Previous observational studies have identified an inverse association of PP with aortic diameter1, and positive associations of PP with aortic wall stiffness and thickness2. However, it is not known whether these associations reflect a causal effect of PP on the risk of AAA, an effect of the aorta on PP, a shared etiology, or confounding from environmental factors.

Description
Keywords
aortic aneurysm, blood pressure, genetics, meta-analysis, population, Aortic Aneurysm, Abdominal, Blood Pressure, Humans, Mendelian Randomization Analysis, Risk Factors
Journal Title
Circ Genom Precis Med
Conference Name
Journal ISSN
2574-8300
2574-8300
Volume Title
Publisher
Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Wellcome Trust (204623/Z/16/Z)
British Heart Foundation (None)
British Heart Foundation (CH/12/2/29428)
British Heart Foundation (RG/18/13/33946)
Medical Research Council (MC_UU_00002/7)