Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis.
| cam.depositDate | 2022-02-07 | |
| cam.issuedOnline | 2022-05-06 | |
| cam.orpheus.counter | 5 | |
| cam.orpheus.success | Wed May 25 11:13:15 BST 2022 - Embargo updated | |
| dc.contributor.author | Burgess, Stephen | |
| dc.contributor.author | Chirinos, Julio A | |
| dc.contributor.author | Damrauer, Scott M | |
| dc.contributor.author | Gill, Dipender | |
| dc.contributor.orcid | Burgess, Stephen [0000-0001-5365-8760] | |
| dc.contributor.orcid | Chirinos, Julio A [0000-0001-9035-5670] | |
| dc.contributor.orcid | Damrauer, Scott M [0000-0001-8009-1632] | |
| dc.contributor.orcid | Gill, Dipender [0000-0001-7312-7078] | |
| dc.date.accessioned | 2022-02-09T00:30:18Z | |
| dc.date.available | 2022-02-09T00:30:18Z | |
| dc.date.issued | 2022-06 | |
| dc.date.updated | 2022-02-07T15:05:48Z | |
| dc.description.abstract | Pulse pressure (PP), the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), arises due to pulsatile ejection of blood from the left ventricle. Previous observational studies have identified an inverse association of PP with aortic diameter1, and positive associations of PP with aortic wall stiffness and thickness2. However, it is not known whether these associations reflect a causal effect of PP on the risk of AAA, an effect of the aorta on PP, a shared etiology, or confounding from environmental factors. | |
| dc.identifier.doi | 10.17863/CAM.81169 | |
| dc.identifier.eissn | 2574-8300 | |
| dc.identifier.issn | 2574-8300 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/333752 | |
| dc.language.iso | eng | |
| dc.publisher | Ovid Technologies (Wolters Kluwer Health) | |
| dc.publisher.department | Mrc Biostatistics Unit | |
| dc.publisher.url | http://dx.doi.org/10.1161/circgen.121.003575 | |
| dc.rights | All Rights Reserved | |
| dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| dc.subject | aortic aneurysm | |
| dc.subject | blood pressure | |
| dc.subject | genetics | |
| dc.subject | meta-analysis | |
| dc.subject | population | |
| dc.subject | Aortic Aneurysm, Abdominal | |
| dc.subject | Blood Pressure | |
| dc.subject | Humans | |
| dc.subject | Mendelian Randomization Analysis | |
| dc.subject | Risk Factors | |
| dc.title | Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis. | |
| dc.type | Article | |
| dcterms.dateAccepted | 2022-02-03 | |
| prism.publicationName | Circ Genom Precis Med | |
| pubs.funder-project-id | Wellcome Trust (204623/Z/16/Z) | |
| pubs.funder-project-id | British Heart Foundation (None) | |
| pubs.funder-project-id | British Heart Foundation (CH/12/2/29428) | |
| pubs.funder-project-id | British Heart Foundation (RG/18/13/33946) | |
| pubs.funder-project-id | Medical Research Council (MC_UU_00002/7) | |
| pubs.licence-display-name | Apollo Repository Deposit Licence Agreement | |
| pubs.licence-identifier | apollo-deposit-licence-2-1 | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1161/CIRCGEN.121.003575 |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- Pulse pressure and aortic aneurysm_v13.docx
- Size:
- 131.04 KB
- Format:
- Unknown data format
- Description:
- Accepted version
- Licence
- http://www.rioxx.net/licenses/all-rights-reserved