The aim of this research is to provide an integrated framework for supporting the design of commercially viable supply chains (SCs) towards delivering value-added intermediates or end-products based on renewable chemical feedstocks. To that end, we first provide the inclusive hierarchical decision-making process that applies to all stakeholders involved in the design and management of circular SCs arising from renewable chemical feedstock platform technologies. We then propose a framework that captures SC configuration opportunities based on four essential pillars including: (i) renewable chemical feedstocks, (ii) production process technologies, (iii) markets, and (iv) value and viability. We conclude by identifying key elements that need to be considered for ensuring the viability of the defined circular supply networks.