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Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.

Published version
Peer-reviewed

Repository DOI


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Authors

Aung, Htin Lin 
Tun, Thanda 
Moradigaravand, Danesh 
Köser, Claudio U 
Nyunt, Wint Wint 

Abstract

Drug-resistant tuberculosis (TB) is a major health threat in Myanmar. An initial study was conducted to explore the potential utility of whole-genome sequencing (WGS) for the diagnosis and management of drug-resistant TB in Myanmar. Fourteen multidrug-resistant Mycobacterium tuberculosis isolates were sequenced. Known resistance genes for a total of nine antibiotics commonly used in the treatment of drug-susceptible and multidrug-resistant TB (MDR-TB) in Myanmar were interrogated through WGS. All 14 isolates were MDR-TB, consistent with the results of phenotypic drug susceptibility testing (DST), and the Beijing lineage predominated. Based on the results of WGS, 9 of the 14 isolates were potentially resistant to at least one of the drugs used in the standard MDR-TB regimen but for which phenotypic DST is not conducted in Myanmar. This study highlights a need for the introduction of second-line DST as part of routine TB diagnosis in Myanmar as well as new classes of TB drugs to construct effective regimens.

Description

Keywords

Drug-resistant TB, Myanmar, Whole-genome sequencing, Antitubercular Agents, Drug Resistance, Multiple, Bacterial, Genome, Bacterial, Humans, Microbial Sensitivity Tests, Mutation, Myanmar, Mycobacterium tuberculosis, Tuberculosis, Multidrug-Resistant

Journal Title

J Glob Antimicrob Resist

Conference Name

Journal ISSN

2213-7165
2213-7173

Volume Title

6

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (098600/Z/12/Z)
Professor Sandy Smith Memorial Scholarship