Repository logo

The McKittrick–Wheelock syndrome: a rare cause of curable diabetes

Change log


Challis, Benjamin G 
Lim, Chung Thong 
Cluroe, Alison 
Cameron, Ewen 


McKittrick–Wheelock syndrome (MWS) is a rare consequence of severe dehydration and electrolyte depletion due to mucinous diarrhoea secondary to a rectosigmoid villous adenoma. Reported cases of MWS commonly describe hypersecretion of mucinous diarrhoea in association with dehydration, hypokalaemia, hyponatraemia, hypochloraemia and pre-renal azotemia. Hyperglycaemia and diabetes are rarely reported manifestations of MWS. Herein we describe the case of a 59-year-old woman who presented with new-onset diabetes and severe electrolyte derangement due to a giant rectal villous adenoma. Subsequent endoscopic resection of the tumour cured her diabetes and normalised electrolytes. This case describes a rare cause of ‘curable diabetes’ and indicates hyperaldosteronism and/or whole-body potassium stores as important regulators of insulin secretion and glucose homeostasis.



1103 Clinical Sciences, Clinical Medicine and Science, Diabetes, Metabolic and Endocrine, 2.1 Biological and endogenous factors

Journal Title

Endocrinology, Diabetes and Metabolism Case Reports

Conference Name

Journal ISSN


Volume Title



BioScientifica Ltd.
This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.