Protein-directed ribosomal frameshifting temporally regulates gene expression
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Peer-reviewed
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Abstract
Programmed −1 ribosomal frameshifting is a mechanism of gene expression, whereby specific signals within messenger RNAs direct a proportion of translating ribosomes to shift −1 nt and continue translating in the new reading frame. Such frameshifting normally occurs at a set ratio and is utilized in the expression of many viral genes and a number of cellular genes. An open question is whether proteins might function as
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2041-1723
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Biotechnology and Biological Sciences Research Council (BB/J007072/1)
Medical Research Council (MR/M011747/1)
European Research Council (646891)
Wellcome Trust (088789/Z/09/Z)
Wellcome Trust (106207/Z/14/Z)
Wellcome Trust (202797/Z/16/Z)