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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Accepted version
Peer-reviewed

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Authors

Bentley, Amy R 
Sung, Yun J 
Brown, Michael R 
Winkler, Thomas W 
Kraja, Aldi T 

Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Description

Keywords

Adolescent, Adult, Aged, Aged, 80 and over, Female, Genome-Wide Association Study, Genotype, Humans, Life Style, Linkage Disequilibrium, Lipids, Male, Middle Aged, Smoking, Young Adult

Journal Title

Nature Genetics

Conference Name

Journal ISSN

1061-4036
1546-1718

Volume Title

51

Publisher

Springer Nature

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_UU_12015/1)
MRC (MC_PC_13048)
MRC (MC_PC_13046)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Medical Research Council (MC_PC_13048)
Medical Research Council (MC_PC_13046)
This project was largely supported by a grant from the US National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL118305) and by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (Z01HG200362).