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Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.

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Published version
Peer-reviewed

Repository DOI


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Authors

Jang, Haeyoon 
Shi, Qiaoxin 
Strain, Tessa 

Abstract

BACKGROUND: Excess sedentary time (ST) is recognized as an important modifiable risk factor for coronary heart disease (CHD). However, whether the associations of genetic susceptibility with CHD incidence can be modified by replacing wearable-device-measured ST with physical activity (PA) is unknown. OBJECTIVES: To examine the associations of wearable-device-measured ST replaced by PA with incident CHD across strata of genetic susceptibility. METHODS: This study included 77,500 White British (57% female) with valid wrist-worn accelerometry and without prevalent CHD/stroke from UK Biobank. Genetic susceptibility to CHD was quantified through weighted polygenic risk scores for CHD based on 300 single-nucleotide polymorphisms. Wrist-worn accelerometer data were used to derive ST, light PA, and moderate-to-vigorous PA (MVPA). RESULTS: Reallocation of 60 min/day of ST into the same amount of MVPA was associated with approximately 9% lower relative risk of CHD for all participants and across strata of genetic risk: replacement of 1 min/day of ST associated with <1% lower relative risk of CHD. No evidence of interaction (p: 0.784) was found between genetic risk and ST for CHD risk. Reallocating 60 min/day of ST into the same MVPA time was associated with greater absolute CHD risk reductions at high genetic risk (0.27%) versus low genetic risk (0.15%). CONCLUSIONS: Replacing any amount of ST with an equal amount of MVPA time is associated with a lower relative risk of CHD, irrespective of genetic susceptibility to CHD. Reductions in CHD absolute risk for replacing ST with MVPA are greater at high genetic risk versus low genetic risk.

Description

Funder: U.S. National Academy of Medicine (NAM)


Funder: Seed Grants of The University of Hong Kong Li Ka Shing Faculty of Medicine

Keywords

UK Biobank, coronary heart disease, genetic risk, physical activity, sedentary behavior, Humans, Female, Male, Sedentary Behavior, Exercise, Risk Factors, Accelerometry, Genetic Risk Score

Journal Title

J Intern Med

Conference Name

Journal ISSN

0954-6820
1365-2796

Volume Title

Publisher

Wiley
Sponsorship
Medical Research Council (MC_UU_12015/3)
MRC (MC_UU_00006/1)
MRC (MC_UU_00006/4)
National Institute for Health and Care Research (IS-BRC-1215-20014)
MRC (MC_UU_00006/6)