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5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study

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Ragnhildstveit, Anya  ORCID logo
Khan, Ryan 
Seli, Paul 
Bass, Lisa Claire 
August, River Jude 


jats:pPsychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy-jats:italicN,N</jats:italic>-dimethyltryptamine (5-MeO-DMT)—a serotonergic psychedelic—as a novel, fast-acting therapeutic. Yet, few studies have directly examined 5-MeO-DMT for trauma- or stress-related psychopathology, including post-traumatic stress disorder (PTSD). Herein, we present the first longitudinal case study on 5-MeO-DMT for chronic refractory PTSD, in a 23-year-old female. A single dose of vaporized bufotoxin of the Sonoran Desert Toad (jats:italicIncilius alvarius</jats:italic>), containing an estimated 10−15 mg of 5-MeO-DMT, led to clinically significant improvements in PTSD, with next-day effects. This was accompanied by marked reductions in hopelessness and related suicide risk. Improvements, across all constructs, were sustained at 1-, 3-, 6-, and 12-months follow-up, as monitored by a supporting clinician. The subject further endorsed a complete mystical experience, hypothesized to underly 5-MeO-DMT’s therapeutic activity. No drug-related, serious adverse events occurred. Together, results showed that 5-MeO-DMT was generally tolerable, safe to administer, and effective for PTSD; however, this was not without risk. The subject reported acute nausea, overwhelming subjective effects, and late onset of night terrors. Further research is warranted to replicate and extend these findings, which are inherently limited, non-generalizable, and rely on methods not clinically accepted.</jats:p>



3214 Pharmacology and Pharmaceutical Sciences, 32 Biomedical and Clinical Sciences, Biotechnology, Behavioral and Social Science, Post-Traumatic Stress Disorder (PTSD), Brain Disorders, Mental Health, Mental health, 3 Good Health and Well Being

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Frontiers in Psychiatry

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Frontiers Media SA
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