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Home and away: clonal hematopoiesis in sibling transplants.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Fabre, Margarete A 
Vassiliou, George S 

Abstract

CH is the disproportionate clonal expansion of blood stem cells and their progeny driven by leukemia-associated somatic mutations and is associated with an increased risk of hematologic cancers and ischemic cardiovascular disease. Reassuringly, the incidence and genetic drivers of CH, in either donors or recipients, did not seem to differ from that reported for unselected individuals of similar ages. Interestingly, the study also reports on the posttransplant behavior of 5 cases of donor-engrafted CH. This scenario uniquely captures the impact of the transplant procedure and 2 different hematopoietic environments on the behavior of the same CH clone. The authors report greater clonal expansion in recipients with donor-engrafted CH compared with the growth of the same founder clone in donors, thus highlighting important features of CH biology.

Description

Keywords

Clonal Hematopoiesis, Hematopoiesis, Hematopoietic Stem Cell Transplantation, Humans, Siblings, Survivors

Journal Title

Blood

Conference Name

Journal ISSN

0006-4971
1528-0020

Volume Title

135

Publisher

American Society of Hematology

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_PC_12009)
Medical Research Council (MC_PC_17230)
Cancer Research UK (23015)