Reproducibility of cardiac 31P MRS at 7 T


Type
Conference Object
Change log
Authors
Ellis, Jane 
Valkovic, Ladislav 
Purvis, Lucian AB 
Clarke, William T 
Rodgers, CT 
Abstract

Synopsis Cardiac PCr/ATP ratios measured by P MRS change in cardiovascular disease giving them value as a biomarker. We scanned 13 healthy volunteers at 7T, assessing their PCr/ATP with 6 ½ min P CSI scans. These data have better reproducibility than a 30min 3T protocol previously published by our centre. Repeated PCr/ATP measurements from subjects in this study were not significantly (P=0.83) different. Measurements were significantly different (P<0.001) from DCM patient data acquired in a previous 7T study using the same coil and pulse sequence. This data will allow us to plan future 7T P-MRS clinical studies.

Description
Keywords
Journal Title
Proceedings of the International Society for Magnetic Resonance in Medicine
Conference Name
ISMRM 2018
Journal ISSN
Volume Title
Publisher
International Society for Magnetic Resonance in Medicine
Sponsorship
Wellcome Trust (Unknown)
Funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (Grant No. 098436/Z/12/Z). JE receives a DPhil (PhD) studentship from the Medical Research Council (UK).