Reproducibility of cardiac 31P MRS at 7 T

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Ellis, Jane 
Valkovic, Ladislav 
Purvis, Lucian AB 
Clarke, William T 
Rodgers, CT 

Synopsis Cardiac PCr/ATP ratios measured by P MRS change in cardiovascular disease giving them value as a biomarker. We scanned 13 healthy volunteers at 7T, assessing their PCr/ATP with 6 ½ min P CSI scans. These data have better reproducibility than a 30min 3T protocol previously published by our centre. Repeated PCr/ATP measurements from subjects in this study were not significantly (P=0.83) different. Measurements were significantly different (P<0.001) from DCM patient data acquired in a previous 7T study using the same coil and pulse sequence. This data will allow us to plan future 7T P-MRS clinical studies.

Journal Title
Proceedings of the International Society for Magnetic Resonance in Medicine
Conference Name
ISMRM 2018
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Volume Title
International Society for Magnetic Resonance in Medicine
Wellcome Trust (Unknown)
Funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (Grant No. 098436/Z/12/Z). JE receives a DPhil (PhD) studentship from the Medical Research Council (UK).