Repository logo
 

Prevention and Management Strategies for Diabetic Neuropathy.

Published version
Peer-reviewed

Change log

Authors

Normahani, Pasha 
Hohenschurz-Schmidt, David  ORCID logo  https://orcid.org/0000-0002-1964-6069

Abstract

Diabetic neuropathy (DN) is a common complication of diabetes that is becoming an increasing concern as the prevalence of diabetes rapidly rises. There are several types of DN, but the most prevalent and studied type is distal symmetrical polyneuropathy, which is the focus of this review and is simply referred to as DN. It can lead to a wide range of sensorimotor and psychosocial symptoms and is a major risk factor for diabetic foot ulceration and Charcot neuropathic osteoarthropathy, which are associated with high rates of lower limb amputation and mortality. The prevention and management of DN are thus critical, and clinical guidelines recommend several strategies for these based on the best available evidence. This article aims to provide a narrative review of DN prevention and management strategies by discussing these guidelines and the evidence that supports them. First, the epidemiology and diverse clinical manifestations of DN are summarized. Then, prevention strategies such as glycemic control, lifestyle modifications and footcare are discussed, as well as the importance of early diagnosis. Finally, neuropathic pain management strategies and promising novel therapies under investigation such as neuromodulation devices and nutraceuticals are reviewed.

Description

Keywords

diabetes, diabetic neuropathy, distal symmetrical polyneuropathy, glycemic control, lifestyle modifications, footcare, diagnostic evaluation, pain management, neuromodulation, nutraceuticals

Journal Title

Life (Basel)

Conference Name

Journal ISSN

2075-1729
2075-1729

Volume Title

Publisher

MDPI AG