dc.contributor.author	Martin-Ruiz, Carmen
dc.contributor.author	Hoffmann, Jedrzej
dc.contributor.author	Shmeleva, Evgeniya
dc.contributor.author	Zglinicki, Thomas von
dc.contributor.author	Richardson, Gavin
dc.contributor.author	Draganova, Lilia
dc.contributor.author	Redgrave, Rachael
dc.contributor.author	Collerton, Joanna
dc.contributor.author	Arthur, Helen
dc.contributor.author	Keavney, Bernard
dc.contributor.author	Spyridopoulos, Ioakim
dc.contributor.orcid	Shmeleva, Evgeniya [0000-0002-7654-2960]
dc.contributor.orcid	Richardson, Gavin [0000-0002-2310-9987]
dc.contributor.orcid	Draganova, Lilia [0000-0003-1371-104X]
dc.contributor.orcid	Keavney, Bernard [0000-0001-9573-0812]
dc.contributor.orcid	Spyridopoulos, Ioakim [0000-0002-2750-2444]
dc.date.accessioned	2021-01-20T16:20:18Z
dc.date.available	2021-01-20T16:20:18Z
dc.date.issued	2020-01-21
dc.date.submitted	2019-06-25
dc.date.updated	2021-01-20T16:20:17Z
dc.description	Funder: The author is supported by the British Heart Foundation
dc.description	Funder: British Heart Foundation PG/15/85/31744 and PG/18/25/33587, Newcastle Healthcare Charity, Medical Research Council (G0500997 to TK, CJ and TvZ, G0601333 to TvZ) and the NIHR Biomedical Research Centre in Ageing and Chronic Disease.
dc.description	Funder: BK holds a British Heart Foundation personal chair.
dc.description.abstract	Abstract: Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse circulating T cells in 597 octogenarians from the same birth cohort together with NT-proBNP measurements and followed all participants over 7 years. We found that, independent of CMV serostatus, a high number of CD27−CD28+ CD8 EMRA T-lymphocytes (TEMRA) protected from all-cause death after adjusting for known risk factors, such as heart failure, frailty or cancer (Hazard ratio 0.66 for highest vs lowest tertile; confidence interval 0.51–0.86). In addition, CD27−CD28+ CD8 EMRA T-lymphocytes protected from both, non-cardiovascular (hazard ratio 0.59) and cardiovascular death (hazard ratio 0.65). In aged mice treated with the senolytic navitoclax, in which we have previously shown a rejuvenated cardiac phenotype, CD8 effector memory cells are decreased, further indicating that alterations in T cell subpopulations are associated with cardiovascular ageing. Future studies are required to show whether targeting immunosenescence will lead to enhanced life- or healthspan.
dc.identifier.doi	10.17863/CAM.63621
dc.identifier.eissn	2056-3973
dc.identifier.other	s41514-019-0041-y
dc.identifier.other	41
dc.identifier.uri	https://www.repository.cam.ac.uk/handle/1810/316513
dc.language	en
dc.publisher	Nature Publishing Group UK
dc.rights	Attribution 4.0 International (CC BY 4.0)	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Brief Communication
dc.subject	/692/53
dc.subject	/631/80/509
dc.subject	brief-communication
dc.title	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
dc.type	Article
dcterms.dateAccepted	2019-12-19
prism.issueIdentifier	1
prism.publicationName	npj Aging and Mechanisms of Disease
prism.volume	6
rioxxterms.licenseref.uri	http://creativecommons.org/licenses/by/4.0/
rioxxterms.version	VoR
rioxxterms.versionofrecord	10.1038/s41514-019-0041-y

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

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