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Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis.

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cam.issuedOnline2022-04-28
dc.contributor.authorSampietro, Anna
dc.contributor.authorPérez-Areales, F Javier
dc.contributor.authorMartínez, Paula
dc.contributor.authorArce, Elsa M
dc.contributor.authorGaldeano, Carles
dc.contributor.authorMuñoz-Torrero, Diego
dc.contributor.orcidSampietro, Anna [0000-0002-1837-2051]
dc.contributor.orcidPérez-Areales, F Javier [0000-0001-9525-9346]
dc.contributor.orcidArce, Elsa M [0000-0003-3757-5468]
dc.contributor.orcidGaldeano, Carles [0000-0003-1702-0369]
dc.contributor.orcidMuñoz-Torrero, Diego [0000-0002-8140-8555]
dc.date.accessioned2022-06-29T19:49:09Z
dc.date.available2022-06-29T19:49:09Z
dc.date.issued2022-04-28
dc.date.updated2022-06-29T19:49:09Z
dc.description.abstractMultitarget anti-Alzheimer agents are the focus of very intensive research. Through a comprehensive bibliometric analysis of the publications in the period 1990-2020, we have identified trends and potential gaps that might guide future directions. We found that: (i) the number of publications boomed by 2011 and continued ascending in 2020; (ii) the linked-pharmacophore strategy was preferred over design approaches based on fusing or merging pharmacophores or privileged structures; (iii) a significant number of in vivo studies, mainly using the scopolamine-induced amnesia mouse model, have been performed, especially since 2017; (iv) China, Italy and Spain are the countries with the largest total number of publications on this topic, whereas Portugal, Spain and Italy are the countries in whose scientific communities this topic has generated greatest interest; (v) acetylcholinesterase, β-amyloid aggregation, oxidative stress, butyrylcholinesterase, and biometal chelation and the binary combinations thereof have been the most commonly pursued, while combinations based on other key targets, such as tau aggregation, glycogen synthase kinase-3β, NMDA receptors, and more than 70 other targets have been only marginally considered. These results might allow us to spot new design opportunities based on innovative target combinations to expand and diversify the repertoire of multitarget drug candidates and increase the likelihood of finding effective therapies for this devastating disease.
dc.identifier.citationPharmaceuticals (Basel, Switzerland), volume 15, issue 5, page 545
dc.identifier.doi10.17863/CAM.85993
dc.identifier.eissn1424-8247
dc.identifier.issn1424-8247
dc.identifier.other35631371
dc.identifier.otherPMC9146451
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338580
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.publisher.urlhttp://dx.doi.org/10.3390/ph15050545
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1424-8247
dc.sourcenlmid: 101238453
dc.subjectAlzheimer’s disease
dc.subjectanimal models
dc.subjecthybrids
dc.subjectmultifactorial diseases
dc.subjectmultitarget drug design
dc.subjectmultitarget drugs
dc.subjectpolypharmacology
dc.subjecttarget combinations
dc.titleUnveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis.
dc.typeArticle
dcterms.dateAccepted2022-04-25
prism.publicationNamePharmaceuticals (Basel)
pubs.funder-project-idAGAUR (2017SGR106 / 2019LLAV00017)
pubs.funder-project-idMinisterio de Ciencia e Innovación (MCIN) / Agencia Estatal de Investigación (AEI) / ERDF (PID2020-118127RB-I00)
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/ph15050545

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