A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process.
Type
Article
Change log
Authors
Poh, Jian-Siang
Browne, Duncan L
Ley, Steven V
Abstract
A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.
Description
Keywords
0305 Organic Chemistry
Journal Title
React Chem Eng
Conference Name
Journal ISSN
2058-9883
2058-9883
2058-9883
Volume Title
1
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
We are grateful to the Cambridge Home and European Scholarship Scheme (JSP) and EPSRC (DLB and SVL, grant numbers EP/K0099494/1 and EP/K039520/1) for financial support.