Associations between change in physical activity and sedentary time and health-related quality of life in older english adults: the EPIC-Norfolk cohort study.

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Yerrakalva, Dharani 
Hajna, Samantha 
Suhrcke, Marc 
Wijndaele, Katrien 
Westgate, Kate 

BACKGROUND: No previous studies have examined the associations between changes in objectively-measured physical behaviours with follow-up QoL in older adults. Based on cross-sectional evidence, it is biologically plausible that such associations exist. If so, this bolsters the case for the commissioning of activity interventions and for including QoL as an outcome in trials of such interventions. METHODS: We assessed physical behaviours (total physical activity, moderate-to-vigorous physical activity (MVPA), light physical activity, total sedentary time and prolonged sedentary bout time) for 7 days using hip-worn accelerometers at baseline (2006-2011) and follow-up (2012-2016) and health-related quality-of-life (QoL) using EQ-5D questionnaires at follow-up in 1433 participants (≥ 60 years) of the EPIC (European Prospective Investigation into Cancer)-Norfolk study. The EQ-5D summary score was used, with 0 as the worst to 1 as best perceived quality-of-life. We evaluated the prospective associations of baseline physical behaviours with follow-up QoL, and of changes in behaviours with follow-up QoL using multi-level regression. RESULTS: On average, MVPA decreased by 4.0 min/day/year (SD 8.3) for men and 4.0 min/day/year for women (SD 12.0) between baseline and follow-up. Total sedentary time increased by an average 5.5 min/day/yr (SD 16.0) for men and 6.4 min/day/yr (SD 15.0) for women between baseline and follow-up. Mean (SD) follow-up time was 5.8 (1.8) years. We found that higher baseline MVPA and lower sedentary time was associated with higher subsequent QoL (e.g. 1 h/day greater baseline MVPA was associated with 0.02 higher EQ-5D score, 95% CI 0.06, 0.36). More pronounced declines in activity were associated with worse Hr-QoL (0.005 (95% CI 0.003, 0.008) lower EQ-5D per min/day/yr decrease in MVPA). Increases in sedentary behaviours were also associated with poorer QoL (0.002 lower EQ-5D, 95% CI -0.003, -0.0007 per hour/day/yr increase in total sedentary time). CONCLUSIONS: Promotion of physical activity and limiting sedentary time among older adults may improve quality-of-life, and therefore this relationship ought to be included in future cost effectiveness analyses so that greater commissioning of activity interventions can be considered.

Older adults, Physical activity, Quality of life, Sedentary, Male, Humans, Female, Aged, Cohort Studies, Sedentary Behavior, Quality of Life, Cross-Sectional Studies, Exercise
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Health Qual Life Outcomes
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Springer Science and Business Media LLC
Medical Research Council (MR/N003284/1)
MRC (MC_UU_00006/1)
MRC (MC_UU_00006/4)
MRC (MC_UU_00006/6)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Medical Research Council (MC_UU_12015/1)
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MC_UU_12015/4)
National Institute for Health and Care Research (IS-BRC-1215-20014)
The EPIC-Norfolk study (DOI 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC-UU_12015/1) and Cancer Research UK (C864/A14136). DY was funded by a National Institute for Health Research Doctoral Fellowship (DRF-2017-10-121). SH was supported by the Lifelong Health and Wellbeing Cross-Council Programme, the Medical Research Council (MC_UU_12015/4), and Canadian Institutes of Health Research (FRN 146766). KWi and SB were supported by the Medical Research Council (MC_UU_00006/4 and MC_UU_12015/3) and NJW by MC_UU_12015/1. KWe was supported by the NIHR Cambridge Biomedical Research Centre (IS-BRC-1215–20014). SJG and NJW are NIHR Senior Investigators. The University of Cambridge has received salary support in respect of SJG from the NHS in the East of England through the Clinical Academic Reserve.

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