The translation factors of Drosophila melanogaster.

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Marygold, Steven J 
Attrill, Helen 
Lasko, Paul 

Synthesis of polypeptides from mRNA (translation) is a fundamental cellular process that is coordinated and catalyzed by a set of canonical 'translation factors'. Surprisingly, the translation factors of Drosophila melanogaster have not yet been systematically identified, leading to inconsistencies in their nomenclature and shortcomings in functional (Gene Ontology, GO) annotations. Here, we describe the complete set of translation factors in D. melanogaster, applying nomenclature already in widespread use in other species, and revising their functional annotation. The collection comprises 43 initiation factors, 12 elongation factors, 3 release factors and 6 recycling factors, totaling 64 of which 55 are cytoplasmic and 9 are mitochondrial. We also provide an overview of notable findings and particular insights derived from Drosophila about these factors. This catalog, together with the incorporation of the improved nomenclature and GO annotation into FlyBase, will greatly facilitate access to information about the functional roles of these important proteins.

Drosophila melanogaster, translation elongation factor, translation initiation factor, translation recycling factor, translation release factor, translation termination factor, Animals, Drosophila Proteins, Drosophila melanogaster, Eukaryotic Initiation Factors, Mitochondrial Proteins, Peptide Elongation Factors, Protein Biosynthesis, Ribosomal Proteins
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Fly (Austin)
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Informa UK Limited
Medical Research Council (G1000968)
S.J.M. and H.A. are supported by the FlyBase NIH/NHGRI grant U41HG000739 (N. Perrimon, Harvard University, PI; N. H. Brown, University of Cambridge, coPI). P.L. is supported by CIHR grants MOP-44050 and IOP-107945 and by NSERC Discovery Grant RGPIN-2014-06340.