Replication of synthetic recognition-encoded oligomers by ligation of trimer building blocks
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Peer-reviewed
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Abstract
The use of a building block that make three non-covalent base-pairs with a template oligomer leads to high affinity binding and high fidelity replication in a coupling reaction with a primer attached to the template with a covalent base-pair.
Description
Acknowledgements: The authors would like to thank the Engineering and Physical Sciences Research Council (EP/P027067/1), the European Research Council (ERC-2020-AdG-101018984-InfoMols) and the Herchel Smith Fund for funding. D. N.-V. acknowledges the funding support provided by the Fundación General CSIC's ComFuturo programme which has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 101034263.
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Organic Chemistry Frontiers
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2052-4129
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Royal Society of Chemistry (RSC)
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Except where otherwised noted, this item's license is described as Attribution 3.0 International
Sponsorship
Engineering and Physical Sciences Research Council (EP/P027067/1)
H2020 European Research Council (ERC-2020-AdG-101018984-InfoMols)
H2020 European Research Council (ERC-2020-AdG-101018984-InfoMols)