Repository logo
 

Compulsive sexual behavior: Prefrontal and limbic volume and interactions.

Published version
Peer-reviewed

Change log

Authors

Morris, Laurel S 
Kvamme, Timo L 
Hall, Paula 
Birchard, Thaddeus 

Abstract

BACKGROUND: Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV). METHODS: Structural MRI (MPRAGE) data were collected in 92 subjects (23 CSB males and 69 age-matched male HV) and analyzed using voxel-based morphometry. Resting state functional MRI data using multi-echo planar sequence and independent components analysis (ME-ICA) were collected in 68 subjects (23 CSB subjects and 45 age-matched HV). RESULTS: CSB subjects showed greater left amygdala gray matter volumes (small volume corrected, Bonferroni adjusted P < 0.01) and reduced resting state functional connectivity between the left amygdala seed and bilateral dorsolateral prefrontal cortex (whole brain, cluster corrected FWE P < 0.05) compared with HV. CONCLUSIONS: CSB is associated with elevated volumes in limbic regions relevant to motivational salience and emotion processing, and impaired functional connectivity between prefrontal control regulatory and limbic regions. Future studies should aim to assess longitudinal measures to investigate whether these findings are risk factors that predate the onset of the behaviors or are consequences of the behaviors. Hum Brain Mapp 38:1182-1190, 2017. © 2016 Wiley Periodicals, Inc.

Description

Keywords

compulsive sexual behavior, depression, resting state functional MRI, sexual addiction, voxel-based morphometry, Adult, Brain Mapping, Case-Control Studies, Compulsive Behavior, HIV Infections, Humans, Limbic System, Magnetic Resonance Imaging, Male, Prefrontal Cortex, Rest, Sexual Behavior, Young Adult

Journal Title

Hum Brain Mapp

Conference Name

Journal ISSN

1065-9471
1097-0193

Volume Title

38

Publisher

Wiley
Sponsorship
Wellcome Trust (093705/Z/10/Z)
Medical Research Council (G1000183)
Wellcome Trust (093875/Z/10/Z)
Medical Research Council (MR/P008747/1)