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The Aire family expands.

Published version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/294005

Repository DOI

https://doi.org/10.17863/CAM.41113
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Published version (510.18 KB)

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Article

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Authors

Liston, Adrian  ORCID logo  https://orcid.org/0000-0002-6272-4085
Dooley, James  ORCID logo  https://orcid.org/0000-0003-3154-4708

Abstract

T cell tolerance depends upon Aire-expressing cells to purge the T cell repertoire of autoreactive clones. Once thought to be the exclusive domain of thymic epithelial cells, a new study by Yamano et al. (https://doi.org/10.1084/jem.20181430) in this issue of JEM identifies ILC3-like cells in the lymph nodes with similar properties.

Description

Keywords

Epithelial Cells, Immune Tolerance, Lymph Nodes, T-Lymphocytes

Journal Title

J Exp Med

Conference Name

Journal ISSN

0022-1007
1540-9538

Volume Title

216

Publisher

Rockefeller University Press

Publisher DOI

https://doi.org/10.1084/jem.20190246

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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwised noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
Sponsorship
Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0428)
Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0427)

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University of Cambridge Research Outputs (Articles and Conferences)