The role of GDF15 in food intake and appetitive behaviour
| cam.issuedOnline | 2021-11-26 | |
| cam.orpheus.counter | 1 | |
| cam.orpheus.success | Tue Feb 01 19:02:17 GMT 2022 - Embargo updated | |
| dc.contributor.author | Cimino, I | |
| dc.contributor.author | Coll, AP | |
| dc.contributor.orcid | Cimino, I [0000-0003-1397-5408] | |
| dc.date.accessioned | 2021-11-17T00:31:12Z | |
| dc.date.available | 2021-11-17T00:31:12Z | |
| dc.date.issued | 2022-02 | |
| dc.description.abstract | The peptide hormone GDF15 is a potent anorectic factor. Raised circulating levels of GDF15 are seen in a large number of pathological disorders and are associated invariably with adverse clinical outcomes. GDF15 signalling is mediated through GFRAL receptor in the hindbrain. A greater understanding of the mechanisms that drive expression of GDF15 within different tissues has led to the GDF15-GFRAL axis being considered a route through which somatic distress is signalled to the brain. We highlight key recent insights into the role of GDF15 in appetitive behaviour and reflect on the therapeutic potential of the system for disorders of energy balance. | |
| dc.description.sponsorship | UK Medical Research Council (MRC) Metabolic Diseases Unit (MRC_MC_UU_12012/1 and MC_UU_00014/1) | |
| dc.identifier.doi | 10.17863/CAM.78145 | |
| dc.identifier.eissn | 2451-9650 | |
| dc.identifier.issn | 2451-9650 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/330700 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier BV | |
| dc.publisher.url | http://dx.doi.org/10.1016/j.coemr.2021.100299 | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | 3205 Medical Biochemistry and Metabolomics | |
| dc.subject | 32 Biomedical and Clinical Sciences | |
| dc.subject | 3202 Clinical Sciences | |
| dc.subject | 1 Underpinning research | |
| dc.subject | 1.1 Normal biological development and functioning | |
| dc.subject | Neurological | |
| dc.subject | Cancer | |
| dc.subject | Mental health | |
| dc.subject | Metabolic and endocrine | |
| dc.subject | Cardiovascular | |
| dc.title | The role of GDF15 in food intake and appetitive behaviour | |
| dc.type | Article | |
| dcterms.dateAccepted | 2021-11-11 | |
| prism.publicationName | Current Opinion in Endocrine and Metabolic Research | |
| pubs.funder-project-id | MRC (MC_UU_00014/1) | |
| pubs.funder-project-id | Medical Research Council (MC_UU_12012/1) | |
| pubs.funder-project-id | Medical Research Council (MC_PC_12012) | |
| rioxxterms.licenseref.startdate | 2021-11-11 | |
| rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1016/j.coemr.2021.100299 |
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